I really believe I am onto something here though. I have decided to try an active form of B1 and am not sure if I should go with Alltiamine or Coenzymated B-1? Do you have any suggestions? http://www.casereports.in/articles/6/3/Thiamine-Therapy-and-Refeeding-Syndrome-in-Extremely-Low-Birth-Weight-Infants.html

I didnt present with confusion,delirium, and other symptoms he’d expect and there are other diagnoses that may fit better considering my I.I.H and the meds I am on. Nevertheless, I am going for the mri and seeing another neurologist to sort it all out. He did reply, but it was posted to the wrong thread. Again, there has been quite a bit of volume. If you scroll down, you will see it. Here is what he said: Chronic fatigue syndrome (I’ve been experiencing “crashes” after light exercise, any idea why this happens, cellularly?) And thank you for sharing your experience. I can’t understand why such a central nutrient, low risk/high reward therapy is not being considered at all by the medical community. I tried to go up to 150mg a few days ago – with the last 50mg dose at dinner – but that seemed to correlate with an increase in anxiety and insomnia. I cannot say whether this connection is real, as it could be the normal vicissitudes of my anxiety – but it has been severe.My mother’s cancer doctor mentioned that it sounded like I had a major b12 deficiency and that I should try supplements. I did and it worked for a time, giving me improvements, but there was still residual numbness. Which gradually got worse. If you are interested, here is a link to Isabella Wendtz’s blog where she talks about Thiamine and thyroid fatigue, and how she supplemented to help herself with it. https://thyroidpharmacist.com/articles/thiamine-and-thyroid-fatigue/ This advice about thiamine supplementation has given me hope that perhaps I may find some level of improvement to my failing health. I was always a fit, slim and healthy person before Lupron and its effects have been utterly devastating, mentally and physically. I literally feel that nobody, even my family and friends believe what I have gone through. It has been a very lonely experience. The light went off for me when I was reading about Benfotiamine and the author listed the symptoms of Dry Beriberi. I was stunned. I cried. I got serious about nutrition, vitamins and minerals. This led me further into studying B1, and now to Dr. Lonsdale and his very important work.

Could you comment on foods and supplements that destroys B1 transport? My lab cited blueberries and raw fish as antithiminase. I was eating berries everyday because of low sugar content and taking resveratrol and 88% dark chocolate, which happen to be the only two of the few foods that I like that I’m not allergic to. I do not eat sushi anymore, because of toxins and white rice. I have an intolerance or sensitivity to many common foods. I’m paleo 80% of the time and do not eat dairy or gluten. Whenever I eat too much of one food, I develop a IGE or IGG response, I’m sure this is due to the B1 deficiency and hoping the inflammation will go down in time. I don’t have enzyme activity to breakdown sulfur, SOD and histamine nor transport folate, so vegetable nutrients aren’t being absorbed. I read Many thanks for your speedy reply – it’s very much appreciated! We have corresponded before regarding Lupron and the truly appalling effects it has on the body.

I gave thiamine a try (Thiamine Mononitrate) 50 mg but after a couple of days, I had some bad reaction to the product (tachycardia, worst dysautonomia upon standing). I was surprised because the dose is fairly minimal compared to those of other patients (some take north of 1g). I was wondering if this is the kind of paradox you have seen in the past? Do you think it is due to the mononitrate part of the product or thiamine itself? Should I try thiamine HCL instead?

Well, maybe the issue was that I didn’t eat enough fat when I took it? I eat 2 salmon fillets whenever I take the allithamine and it works great to help me absorb it. burnout, Histamine intolerance (possible MCAS) and also exercise intolerance..muscles feel kind of sore and heavy and painful after very little exercise, walking upstairs will feel very exhausting in calves and I have to stop and let muscles recover… more than 15 min exercise will result in fatigue/exhaustion, red head/flushing/hot flashes and migraines…

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From what I’ve since read, I realise this is likely paradox symptoms. I’m now on btwen 62.5-125mg (1/4 – 1/2 tab) daily, and I find I still have to take the dose at night. Daytime doses make me too tired. Personally, I am taking 50 mg of TTFD and 100 mg of sulbutiamine daily (as well as 150 mg of benfotiamine and 500 mg of thiamine hydrochloride). However, that doesn’t mean that would be right for you. When I first came across all this info on thiamine I started supplementing and the worst of my mental confusion, nausea, loss of appetite went away within a few days. I stopped the B1 because of gut pain and the symptoms increased again, I then restarted the B1 and they decreased again. (Unfortunately I had been supplementing for a bit before performing the test but intermittently) I am now using the Authia cream since I struggle with oral supplementation. I have noticed that I feel really tired after applying the cream for most of the day. I seem to remember reading that this would also suggest deficiency as otherwise supplementing would have no effect. Since you indicate that TTFD is better absorbed that Thiamine HCL, I am assuming that smaller doses of TTFD are more effective that Thiamine HCL. Is there any general dose equivalent between these substances?